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isoniazid will increase the degree or outcome of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Stay clear of coadministration of pazopanib with potent CYP3A4 inhibitors if at all possible; if ought to coadminister, decrease pazopanib dose to 400 mg/dayexpression in gastric cancer cells. ARV-825 treatment sig